AEMCA Practice Exam 2025 – 400 Free Practice Questions to Pass the Exam

Smallpox is considered one of the most devastating infectious diseases in history due to its high transmission rates and significant mortality impact before its eradication. The World Health Organization declared smallpox eradicated in 1980, making it the first human disease to be eliminated globally. The disease is caused by the variola virus and is characterized by fever, body aches, and a distinctive rash, often leading to severe scarring and, in many cases, death.

Smallpox had profound effects on populations throughout history, causing millions of deaths and shaping societies. Its capacity to decimate populations made it notoriously lethal, impacting both public health and social dynamics across various regions. The global vaccination campaign that led to its eradication showcased the effectiveness of vaccination programs, establishing a benchmark for future efforts against infectious diseases.

In contrast, while influenza, Ebola, and the plague have also caused significant suffering and loss of life, smallpox's eradication and historical impact set it apart as particularly devastating within the scope of infectious diseases.